linear microelectrode arrays (lma  (Alpha-Omega Engineering)

Journal: American Journal of Physiology - Heart and Circulatory Physiology

Article Title: Premature ventricular contractions activate vagal afferents and alter autonomic tone: implications for premature ventricular contraction-induced cardiomyopathy

doi: 10.1152/ajpheart.00286.2019

Figure Lengend Snippet: Nodose ganglia in vivo neuronal recordings. A: anatomic locations of the nodose ganglion and carotid artery are shown. Protein gene product (PGP) 9.5 staining of the nodose ganglion was used to confirm location of the ganglion at the end of the experiments. B: customized 16-channel linear microelectrode array was used for individual neuronal recordings. C: representative sorted neuronal action potentials from the nodose ganglion of 1 animal. Representative action potentials from individual neurons are illustrated in the boxes. D: representative activities generated by 6 nodose neuronal soma in response to premature ventricular contractions (PVCs) in 1 animal. Increase in the activity of these nodose neurons (P < 0.05) can be observed during PVCs in this animal. CH, electrode channel; LVP, left ventricular pressure (mmHg).

Article Snippet: As no differences in the transduction capabilities of left versus right nodose ganglion have been previously observed ( 44 ), left ( n = 3), right ( n = 4), or bilateral ( n = 9) nodose ganglion soma activity was recorded in vivo using custom-made 16-channel linear microelectrode arrays (LMA; Microprobes for Life Science, Gaithersburg, MD; ).

Techniques: In Vivo, Staining, Microelectrode Array, Generated, Activity Assay